Desenvolvimento de um antisséptico bucal a partir da euclea natalensis (Mulala)

Abstract

In this work, a mouthwash was developed and tested from Euclea natalensis, but before that, laboratory experiments were carried out with the aim of identifying whether Euclea natalensis could be applied in this process without harming oral health and having the desired effect. The physicochemical characterization of the root of this plant as well as its aqueous extract was carried out. The methodology used consisted of a bibliographic search where research and systematization of information related to the subject was carried out, an experimental part, where the Euclea natalensis root was characterized, infrared spectrophotometric analysis was performed to identify the presence or absence of naphthoquinones, the reduction of the pigments that give color by adsorption with bentonite and the antimicrobial tests of the crude and clean aqueous extract of Euclea natalensis to evaluate its antimicrobial activity and determine MIC. From the results of the characterization, it was found that Euclea natalensis presents naphthoquinones in its structure, according to IV, therefore the use of this root in the production of mouthwash is justified, since naphthoquinones are substances with antibacterial, antifungal, antimicrobial and anti-inflammatory action. The density and viscosity of the aqueous extract of Euclea natalensis were determined based on the average standard density and viscosity of commercial mouthwashes, therefore the density was adjusted to 1.2071 g/ml against 1.1 425±0.0200 g/ml of commercial mouthwashes, and viscosity of 12.61 00cP against 12.4000±0.0200cP of commercial mouthwashes. To improve the color of the antiseptic, the aqueous extract of Euclea natalensis was adsorbed using bentonite, which reduced the pigments responsible for the color by approximately 20% and in the antimicrobial analysis it was found that the two aqueous extracts (raw and clean) have antimicrobial activity against the microorganisms Staphylococcus aureus, Streptococcus muntans and Porphyromanas gingivalis, microorganisms that can be found in the oral cavity.(TRADUÇÃO NOSSA)